Riskguard® Hereditary Cancer test

The Riskguard test is an assessment tool that can help uncover hereditary cancer risk. With just a simple blood, saliva or buccal (cheek) swab sample, it checks for hereditary genetic changes that can cause an increased risk for certain cancers.
For providers
See the difference the Riskguard test can make for your patients.
For patients
See the difference the Riskguard test can make for you.
Benefits of the Riskguard test

Being proactive now can make a difference for the future

A health care provider with stethoscope looking at a tablet device with a patient.
Powerful information about hereditary cancer risk
While many people have a history of cancer in their families, only 10-15% of cancers are hereditary.1 By testing for hereditary cancer conditions, patients and healthcare providers can better determine the optimal monitoring or treatment plan. 

The Riskguard test can offer powerful insights for patients who have a family history of cancer, patients who have been newly diagnosed with cancer, and even patients who have already undergone cancer treatment.

A man sitting in a chair receiving chemotherapy, gazing off to the right with a mobile device in his hand.
Tools for personalized treatment and risk-management
The Riskguard test can help patients and providers tailor individualized treatment and risk-management journeys, guided by genetics.2-7
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Results that empower you and your family members
Receive easy-to-understand results with potential next steps that providers and patients can use for personalized care planning.

The Riskguard test can also identify family members at risk and help them make more informed decisions about strategies to reduce their cancer risk. 

The Riskguard test checks 59 genes across 11 common cancer types
Approximately 1 in 8 cancers are due to a hereditary syndrome.1 The Riskguard test helps patients learn more about their genetic risk for some of the most common and aggressive cancer types.

Colorectal     Breast     Prostate     Pancreatic     Ovarian     Endometrial     Skin     Gastric     Kidney     Endocrine     Lung

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The Riskguard test process

Determine whether the Riskguard test is a good fit

Take the test — both in-office and at-home tests are available

Access the results online and discuss next steps

You have coverage options

We understand navigating coverage can be overwhelming. Exact Sciences* is an in-network provider with many health plans. We offer insurance billing and flexible payment options.

  • Coverage for eligible patients including Medicare and commercial insurance†
  • Specialized support for billing insurance and prior authorization
  • Flexible payment options for patients
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We're here for you

With questions about ordering the Riskguard test, insurance billing and payment options, checking results, or getting connected with a genetic counselor, call us at +1 866-662-6897 or email us at riskguard@exactsciences.com.
The Exact Sciences Riskguard test was developed, and its performance characteristics validated by an Exact Sciences laboratory following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. The test is performed in Marshfield, WI at PreventionGenetics LLC, a wholly owned subsidiary of Exact Sciences. PreventionGenetics is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing. It has not been cleared or approved by the US Food and Drug Administration or other notified regulatory authority. Genomic Health, Inc., an Exact Sciences company, is the billing entity for the Riskguard test.